Vacature: Scientist Oxford Nanopore Sequencing
Werkgever:Lonza
Plaats:Geleen
Today, Lonza is a global leader in life sciences operating across three continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.
We are looking for experienced Scientists to work in the field of mRNA Nanopore Sequencing with strong evidence for delivering on commitments and working collaboratively in cross-disciplinary teams. This is a 12 month rolling fixed term contract.
Role Purpose:
- Proficient in executing laboratory activities for development and implementation of mRNA Nanopore Sequencing and hands on experience in performing Sanger sequencing is a must.
- Troubleshoot method challenges in a creative and controlled manner.
- Act as a project manager and technical point of contact in the area of responsibility.
- Design and execute advanced experimental plans and data analysis methods, write, and review high quality reports.
- Sound knowledge of GMP and GDP.
- Hands-on experience of method validation as per various regulatory guidelines like ICH, USP is required while equipment qualification experience is desirable.
- Provide strong scientific, technical, and regulatory leadership at project level.
- Understanding of data analysis tools and relevant statistical methods.
- Implementation of Design of Experiments (DoE), and qualification/validation for regulated analytical or bioanalytical assays
Key Accountabilities and Duties:
- Practical experience of the applied use of nanopore sequencing of DNA and direct sequencing of RNA and/or methylation sequencing within both research and industry settings.
- Demonstrated proficiency in sample processing, performing quality control assessments using tools such as FastQC,, as well as executing library preparation and sequencing protocols on Oxford Nanopore devices.
- Hands-on experience in the comprehensive analysis and visualization of sequencing data using various software, or proficiency in developing custom pipelines to extract meaningful insights from sequencing datasets.
- Prior work experience in Quality Control laboratory is a plus.
- Practical experience of method development and validation to regulatory standards is of benefit.
- Experience of using Linux/Unix, scripting, python-based data analysis. Execute laboratory activities for development and implementation of mRNA nanopore sequencing.
- Knowledge in performing enzymatic assays and HPLC analytics is preferred but not essential
- Design and execute DoE studies & high-throughput screen for analytical methods improvements and advancements
- Demonstrated ability to efficiently work in a fast paced and fluid environment, changes in priority and timeline restrictions
Qualifications:
- MSc, and or PhD degree in a relevant field like Molecular Biology/Biotechnology-based field, and several years of related industry experience - preferably in an RNA-related field.
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People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.
